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Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury  Christine S Rinder, MD, Manuel Fontes, MD,

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Presentation on theme: "Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury  Christine S Rinder, MD, Manuel Fontes, MD,"— Presentation transcript:

1 Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury  Christine S Rinder, MD, Manuel Fontes, MD, Joseph P Mathew, MD, Henry M Rinder, MD, Brian R Smith, MD  The Annals of Thoracic Surgery  Volume 75, Issue 3, Pages (March 2003) DOI: /S (02)

2 Fig 1 Polymorphonuclear (PMN) CD11b expression during and after cardiopulmonary bypass (CPB). Surface expression of PMN CD11b was measured preoperatively for baseline values just before aortic cross-clamp release (PRE-XCR), 10 minutes after cross-clamp release (10M POST XCR), on intensive care unit arrival (ICU), and 18 hours after CPB (18H POST CPB). The mean ± standard error of the mean PMN CD11b levels for these time points are displayed, expressed as a percentage of the preoperative value. Hatched bars represent patients whose peak postoperative creatinine remained less than 150% of their baseline. Solid bars represent acute renal insufficiency patients whose peak postoperative creatinine increased to greater than or equal to 150% of their baseline. Acute renal insufficiency patients demonstrated significantly greater PMN CD11b levels than did patients with more preserved renal function (p = 0.01; analysis of variance). The Annals of Thoracic Surgery  , DOI: ( /S (02) )

3 Fig 2 Polymorphonuclear (PMN) counts during and after cardiopulmonary bypass (CPB). Absolute numbers of PMN were measured at the time points noted in Figure 1 and additionally at 48 hours after CPB (48H POST CPB) and 72 hours after CPB (72H POST CPB). The mean ± standard error of the mean for each time point is displayed. Hatched bars represent patients whose peak postoperative creatinine remained less than 150% of their baseline. Solid bars represent patients whose peak postoperative creatinine increased to greater than or equal to 150% of their baseline. Acute renal insufficiency patients demonstrated significantly greater absolute numbers of PMN than did patients with more preserved renal function (p = 0.045; analysis of variance). (10M POST XCR = 10 minutes after cross-clamp release; 18H POST CPB = 18 hours after cardiopulmonary bypass; ICU = intensive care unit arrival; PRE-XCR = just before aortic cross-clamp release.) The Annals of Thoracic Surgery  , DOI: ( /S (02) )

4 Fig 3 Myeloperoxidase levels during and after cardiopulmonary bypass. Plasma levels of myeloperoxidase levels (mean ± standard error of the mean) were measured preoperatively (BASE), 10 minutes after cross-clamp release (10M POST XCR), and on intensive care unit arrival (ICU). Hatched bars represent patients whose peak postoperative creatinine remained less than 150% of their baseline. Solid bars represent patients whose peak postoperative creatinine increased to greater than or equal to 150% of their baseline. Acute renal insufficiency patients did not differ significantly from patients with preserved renal function (p = 0.65; analysis of variance). The Annals of Thoracic Surgery  , DOI: ( /S (02) )

5 Fig 4 Monocyte (MONO) CD11b expression during and after cardiopulmonary bypass (CPB). Surface expression of monocyte CD11b (mean ± standard error of the mean) was measured perioperatively at the time points noted in Figure 1. Monocyte CD11b levels are expressed as a percentage of the baseline value. Hatched bars represent patients whose peak postoperative creatinine remained less than 150% of their baseline. Solid bars represent patients whose peak postoperative creatinine increased to greater than or equal to 150% of their baseline. Acute renal insufficiency patients did not differ significantly from patients with preserved renal function (p = 0.09; analysis of variance). (10M Post XCR = 10 minutes after cross-clamp release; 18H POST CPB = 18 hours after cardiopulmonary bypass; ICU = intensive care unit arrival; PRE-XCR = preoperative cross-clamp release.) The Annals of Thoracic Surgery  , DOI: ( /S (02) )

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