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Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats  Sachiko Matsuzaki, M.D., Michel Canis, M.D.,

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Presentation on theme: "Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats  Sachiko Matsuzaki, M.D., Michel Canis, M.D.,"— Presentation transcript:

1 Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats  Sachiko Matsuzaki, M.D., Michel Canis, M.D., Claude Darcha, M.D., Radhouane Dallel, D.D., Kunihiro Okamura, M.D., Gerard Mage, M.D.  Fertility and Sterility  Volume 82, Issue 6, Pages (December 2004) DOI: /j.fertnstert Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 Macroscopic appearance of ectopic implants in site A (A, B) and immunohistochemical staining for Cox-2 in corresponding implants (C, D) in rats treated within protocol-1 (tissue obtained after 4 weeks of treatment). (A, C) Control rat. (B, D) Cox-2 inhibitor–treated rat. Both size and Cox-2 expression of ectopic implants in site A were markedly reduced after 4 weeks of treatment with the Cox-2 inhibitor compared with size and expression in control rats. Bar = 1 mm. Immunohistochemistry; original magnification ×400. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions


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