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A Dramatic Response to Crizotinib in a Non–Small-Cell Lung Cancer Patient with IHC- Positive and FISH-Negative ALK  Jong-Mu Sun, MD, PhD, Yoon-La Choi,

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Presentation on theme: "A Dramatic Response to Crizotinib in a Non–Small-Cell Lung Cancer Patient with IHC- Positive and FISH-Negative ALK  Jong-Mu Sun, MD, PhD, Yoon-La Choi,"— Presentation transcript:

1 A Dramatic Response to Crizotinib in a Non–Small-Cell Lung Cancer Patient with IHC- Positive and FISH-Negative ALK  Jong-Mu Sun, MD, PhD, Yoon-La Choi, MD, PhD, Jae-Kyung Won, MD, Fred R. Hirsch, MD, PhD, Jin Seok Ahn, MD, PhD, Myung-Ju Ahn, MD, PhD, Keunchil Park, MD, PhD  Journal of Thoracic Oncology  Volume 7, Issue 12, Pages e36-e38 (December 2012) DOI: /JTO.0b013e e Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 A, Immunohistochemistry showed moderate ALK protein expression, B, FISH analysis did not show any translocation of ALK gene. ALK, anaplastic lymphoma kinase; FISH, fluorescent in situ hybridization. Journal of Thoracic Oncology 2012 7, e36-e38DOI: ( /JTO.0b013e e) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 A, Chest radiograph and computed tomography at baseline of crizotinib therapy revealed a large primary lung mass and mediastinal lymph nodes with a chest tube in situ. B, Chest images checked at day 32, and C, at day 83 of crizotinib therapy showed significantly decreased tumor. Journal of Thoracic Oncology 2012 7, e36-e38DOI: ( /JTO.0b013e e) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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