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Characterizing Virological Suppression in Today's Treatment Paradigm

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Presentation on theme: "Characterizing Virological Suppression in Today's Treatment Paradigm"— Presentation transcript:

1 Characterizing Virological Suppression in Today's Treatment Paradigm

2 Key Objectives of This Program

3 Virological Suppression Represents Success for the Patient

4 Definitions of Virological Suppression

5 What Constitutes Virological Failure?

6 How Can We Limit Virological Failure?

7 How Do We Define Success With Highly Efficacious Treatment?

8 Defining Success in Treatment-Naive Patients

9 GEMINI-1 and -2 Phase 3 Study Designs

10 GEMINI-1 and -2 Phase 3 Primary Outcomes

11 GEMINI-1 and -2: Analysis of Participants With TND Over Baseline VL for 2DR and 3DR

12 Considerations for Clinicians

13 FLAIR: Long-Acting Cabotegravir + Rilpivirine for HIV Maintenance

14 FLAIR: Results for Primary and Secondary Endpoints

15 FLAIR: Injection Site Reactions

16 FLAIR: Patient Preference Survey

17 FLAIR: Patients Who Experienced Virologic Failure CAB LA + RPV LA Arm

18 Clinical Case: 48-Year-Old Man

19 Clinical Case: 48-Year-Old Man (cont)

20 Clinical Case: 48-Year-Old Man (cont)

21 Considerations for Clinicians (cont)

22 Clinical Case: 46-Year-Old Woman

23 Clinical Case: 46-Year-Old Woman (cont)

24 SWORD-1 and -2: Analysis of Viral Replication for 2DR vs 3DR

25 Clinical Case: 46-Year-Old Woman (cont)

26 PARTNER Study

27 PARTNER: Key Conclusions

28 Communicating With Patients Regarding Virological Suppression

29 Concluding Remarks

30 Abbreviations

31 Abbreviations (cont)

32 Abbreviations (cont)


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