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Clinical Efficacy and Predictive Molecular Markers of Neoadjuvant Gemcitabine and Pemetrexed in Resectable Non-small Cell Lung Cancer  Gerold Bepler,

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Presentation on theme: "Clinical Efficacy and Predictive Molecular Markers of Neoadjuvant Gemcitabine and Pemetrexed in Resectable Non-small Cell Lung Cancer  Gerold Bepler,"— Presentation transcript:

1 Clinical Efficacy and Predictive Molecular Markers of Neoadjuvant Gemcitabine and Pemetrexed in Resectable Non-small Cell Lung Cancer  Gerold Bepler, MD, PhD, K Eric Sommers, MD, Alan Cantor, PhD, Xueli Li, MD, Anupama Sharma, MD, Charles Williams, MD, Alberto Chiappori, MD, Eric Haura, MD, Scott Antonia, MD, PhD, Tawee Tanvetyanon, MD, George Simon, MD, Coleman Obasaju, MD, Lary A. Robinson, MD  Journal of Thoracic Oncology  Volume 3, Issue 10, Pages (October 2008) DOI: /JTO.0b013e Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Water fall plots of radiographic disease response and mRNA gene expression. Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e ) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Kaplan-Meier overall and disease-free survival (OS and DFS) estimates. The black curve denotes OS and the red curve DFS. Tick marks indicate censored cases. Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e ) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Pretreatment and posttreatment mRNA levels of the genes RRM1 and TS in 10 patients. Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e ) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

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