1. Reproductive BioMedicine Online
Controversies in ART: can the IVF laboratory influence preimplantation embryo aneuploidy? 
Jason E. Swain 
Reproductive BioMedicine Online 
DOI: /j.rbmo
Copyright © 2019 Reproductive Healthcare Ltd. Terms and Conditions

2. Figure 1
Common stressors within the culture system that impact embryo development in vitro and may potentially impact machinery responsible for proper mitotic cell division and separation/segregation of chromosomes. While each stressor alone may not cause a significant increase in aneuploidy, subtle stress from multiple sources may yield a cumulative effect that could explain wide variations in embryo aneuploidy between laboratories reported in the literature.
Reproductive BioMedicine Online DOI: ( /j.rbmo )
Copyright © 2019 Reproductive Healthcare Ltd. Terms and Conditions

3. Figure 2
Increasing media osmolality disrupts the human oocyte meiotic spindle. For every 1 mOsm increase, the spindle is disrupted by an odds ratio of 1.001–1.004 (adapted from Mullen et al., 2004).
Reproductive BioMedicine Online DOI: ( /j.rbmo )
Copyright © 2019 Reproductive Healthcare Ltd. Terms and Conditions

4. Figure 3
Impact of a temperature gradient on mouse embryo morphokinetic (mitotic division) timings and blastocyst development (Walters et al., 2018). Different superscripts within a stage represent statistically significant differences, P < 0.05.
Reproductive BioMedicine Online DOI: ( /j.rbmo )
Copyright © 2019 Reproductive Healthcare Ltd. Terms and Conditions