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6% Hydroxyethyl starch (130/0

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1 6% Hydroxyethyl starch (130/0
6% Hydroxyethyl starch (130/0.4) vs Ringer's lactate preloading before spinal anaesthesia for Caesarean delivery: the randomized, double-blind, multicentre CAESAR trial‡  F.J. Mercier, P. Diemunsch, A.-S. Ducloy-Bouthors, A. Mignon, M. Fischler, J.-M. Malinovsky, F. Bolandard, A.G. Aya, M. Raucoules- Aimé, D. Chassard, H. Keita, A. Rigouzzo, A. Le Gouez  British Journal of Anaesthesia  Volume 113, Issue 3, Pages (September 2014) DOI: /bja/aeu103 Copyright © 2014 The Author(s) Terms and Conditions

2 Fig 1 CONSORT diagram showing disposition for all patients randomized. ITT, intention-to-treat; TR, treatment-received; PP, per-protocol. British Journal of Anaesthesia  , DOI: ( /bja/aeu103) Copyright © 2014 The Author(s) Terms and Conditions

3 Fig 2 Kaplan–Meier curves analysing the onset of maternal hypotension after induction of SA in both treatment groups. The graph shows a significant slower onset rate and lower rate of hypotension in the HES group, when compared with the RL group (P=0.006 by log-rank test). British Journal of Anaesthesia  , DOI: ( /bja/aeu103) Copyright © 2014 The Author(s) Terms and Conditions

4 Fig 3 Serial changes in maternal SAP and DAP after induction of SA. Data are presented as mean (sd). Both SAP and DAP were comparable between the groups at all time-points. Owing to clarity of illustration, for the HES group, only positive sd values and for the RL group, only negative sd values are pictured. British Journal of Anaesthesia  , DOI: ( /bja/aeu103) Copyright © 2014 The Author(s) Terms and Conditions


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