1. Host-Retrovirus Arms Race: Trimming the Budget
Patric Jern, John M. Coffin 
Cell Host & Microbe 
Volume 4, Issue 3, Pages (September 2008)
DOI: /j.chom
Copyright © 2008 Elsevier Inc. Terms and Conditions

2. Figure 1
The Organization of Human APOBEC Loci on Chromosome 22 with the Deaminase Domains, Indicated in Red and Blue, Is Shown in the Upper Left
Also shown is the structure of hA3G with the deaminase domain shaded and the important mutations identified by OhAinle et al. (2008) indicated. The phylogeny of old world primates (black branches) and other mammals (gray branches) is shown below. Approximate times of endogenization of human endogenous retroviruses (HERVs) are indicated above the phylogeny (triangles), and the acquisition of APOBEC genes is indicated below (wide arrow), with a scale, in millions of years (My), shown below. Recent evolution of the four human A3H haplotypes into inactive (red) and active (black) forms is shown in the upper right. Abbreviations: A3A-A3H, APOBEC3A to H; del, deletion; PTC, premature termination codon. (Modified from Bannert and Kurth, 2006; Harris and Liddament, 2004; OhAinle et al., 2008 [this issue]).
Cell Host & Microbe 2008 4, DOI: ( /j.chom )
Copyright © 2008 Elsevier Inc. Terms and Conditions