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Ibrutinib Treatment of CLL: The Cancer Fights Back

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Presentation on theme: "Ibrutinib Treatment of CLL: The Cancer Fights Back"— Presentation transcript:

1 Ibrutinib Treatment of CLL: The Cancer Fights Back
Ryan M. Young, Louis M. Staudt  Cancer Cell  Volume 26, Issue 1, Pages (July 2014) DOI: /j.ccr Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 B Cell Receptor Signaling in Malignant B Cells
Chronic active BCR signaling is shown. Ibrutinib is shown to inhibit BTK. Red asterisks denote signaling effectors that are the target of ibrutinib resistance mutations in CLL patients. Cancer Cell  , 11-13DOI: ( /j.ccr ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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