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Published byŠtefan Dvořák Modified over 5 years ago
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Model of immunosuppressive drug action in lymphocyte activation.
Model of immunosuppressive drug action in lymphocyte activation. CsA and FK506 interact with the immunophilins cyclophilin A or FKBP12, respectively. The protein-drug complexes inhibit calcineurin-dependent dephosphorylation of p-NFATc in the cytosol, preventing its nuclear translocation and transcription of early T-cell activation genes. In contrast, FKBP12-rapamycin complexes inhibit mTOR kinase preventing IL-2 signaling and cell cycle progression from G1 to S. Matthew W. Harding Clin Cancer Res 2003;9: ©2003 by American Association for Cancer Research
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