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Endogenous bradykinin and B1-B5 during angiotensin-converting enzyme inhibitor– associated angioedema  Scott A. Hubers, MD, Kevin Kohm, MS, Shouzuo Wei,

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Presentation on theme: "Endogenous bradykinin and B1-B5 during angiotensin-converting enzyme inhibitor– associated angioedema  Scott A. Hubers, MD, Kevin Kohm, MS, Shouzuo Wei,"— Presentation transcript:

1 Endogenous bradykinin and B1-B5 during angiotensin-converting enzyme inhibitor– associated angioedema  Scott A. Hubers, MD, Kevin Kohm, MS, Shouzuo Wei, PhD, Chang Yu, PhD, Hui Nian, PhD, Ryan Grabert, AM, Daniel J. Sexton, PhD, Nancy J. Brown, MD  Journal of Allergy and Clinical Immunology  Volume 142, Issue 5, Pages e5 (November 2018) DOI: /j.jaci Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Concentrations of bradykinin (A) and its metabolite, BK1-5 (B), as well as the molar ratio of bradykinin to BK1-5 (C), in patients presenting with ACE inhibitor–associated angioedema (case) and in ACE inhibitor–treated control subjects. Plots show individual data and medians with interquartile ranges. ID numbers are provided for subjects with a value greater than 2 SDs more than the mean for control subjects. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Concentrations of bradykinin (A) and its metabolite, BK1-5 (B), as well as the molar ratio of bradykinin to BK 1-5 (C), in blood samples collected during ACE inhibitor–associated angioedema (Acute) and after resolution of symptoms (Convalescent). Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 cHMWK concentrations measured in plasma from ACE inhibitor–treated control subjects without angioedema, patients during acute presentation with ACE inhibitor–associated angioedema (Case), and after resolution of angioedema (Case Convalescent). Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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