1. Identity Crisis: It’s Not Just Foxp3 Anymore
Greg M. Delgoffe, Matthew L. Bettini, Dario A.A. Vignali 
Immunity 
Volume 37, Issue 5, Pages (November 2012)
DOI: /j.immuni
Copyright © 2012 Elsevier Inc. Terms and Conditions

2. Figure 1
TCR-Induced CpG Hypomethylation of Treg Cell Signature Genes Facilitates Treg Cell Development and Stability
Treg cells lacking nTreg-Me (methylation is depicted with white triangles) are more plastic and display decreased suppressive function and potential loss of Foxp3 expression. Strong TCR signals in the thymus or continuous TCR signals in the periphery can induce nTreg-Me in several Treg cell signature genes, although there might be additional signals that further influence the development of the nTreg-Me phenotype in T cells.
Immunity  , DOI: ( /j.immuni )
Copyright © 2012 Elsevier Inc. Terms and Conditions