1. A Long-Distance Relay-tionship between Tumor and Bone
Klara Soukup, Johanna A. Joyce 
Immunity 
Volume 48, Issue 1, Pages (January 2018)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Lung Tumors Can Engage Distant Osteoblasts to Drive Pro-tumoral Granulopoiesis
Through the systemic release of the soluble receptor for advanced glycation end products (sRAGE), lung tumors signal to remote bone-resident osteoblasts (in blue). This signal leads to osteoblast activation, which in turn promotes the generation of a specific subset of tumorigenic neutrophils. Sialic acid-binding immunoglobulin-like lectin F high-expressing (SiglecFhi) neutrophils (in green) are thereby mobilized in circulation to the primary tumor site, where they can promote cancer progression. SiglecFhi neutrophils gradually obtain their tumor-promoting phenotype as they travel toward the tumor tissue, where their education into potent tumor-enhancing cells can be completed (shaded green of increased intensity).
Immunity  , 13-16DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions