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Cell Biology: Capturing Formin’s Mechano-Inhibition

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1 Cell Biology: Capturing Formin’s Mechano-Inhibition
Dimitrios Vavylonis, Brandon G. Horan  Current Biology  Volume 27, Issue 19, Pages R1078-R1080 (October 2017) DOI: /j.cub Copyright © 2017 Elsevier Ltd Terms and Conditions

2 Figure 1 Schematic of experiments and results by Zimmermann et al. [6]. (A) In vitro reconstitution experiment of fission yeast nodes. Actin filament elongation rate by formin Cdc12 was reduced upon myosin pulling. (B) Comparison of the Cdc12 and mDia2 FH1 domains and respective mechanosensitive properties. The black line segments represent proline-rich regions that are candidate sites for interaction with profilin and profilin–actin. The gray line in the mDia2 FH1 domain represents a segment with lower proline density. Current Biology  , R1078-R1080DOI: ( /j.cub ) Copyright © 2017 Elsevier Ltd Terms and Conditions


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