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TGFβ1/Smad3 signaling suppresses IFNγ production via an E4BP4-dependent mechanism in NK-92 cells. TGFβ1/Smad3 signaling suppresses IFNγ production via.

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Presentation on theme: "TGFβ1/Smad3 signaling suppresses IFNγ production via an E4BP4-dependent mechanism in NK-92 cells. TGFβ1/Smad3 signaling suppresses IFNγ production via."— Presentation transcript:

1 TGFβ1/Smad3 signaling suppresses IFNγ production via an E4BP4-dependent mechanism in NK-92 cells.
TGFβ1/Smad3 signaling suppresses IFNγ production via an E4BP4-dependent mechanism in NK-92 cells. A, Western blot analysis of Smad3 phosphorylation in NK-92, B, Real-time PCR of E4BP4 mRNA expression in NK-92-EV and NK92-S3KD cells with or without addition of TGFβ1. C, Western blot analysis of E4BP4 protein expression in NK-92 cells treated with 5 ng/mL of TGFβ1. D–F, Real-time PCR, Western blot analysis of E4BP4 and ELISA of IFNγ in NK-92-EV cells treated with Smad3 inhibitor SIS3 (5 μmol/L) and TGFβ1 (5 ng/mL). Data represent mean ± SD for three independent experiments. *, P < 0.05; **, P < 0.01; ***, P < versus blank control (0 ng/mL of TGFβ1); ###, P < versus NK-92-EV or TGFβ1-treated only. Qing-Ming Wang et al. Cancer Immunol Res 2018;6: ©2018 by American Association for Cancer Research

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