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Notch 1 Keeps Pro-T cells on Track

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Presentation on theme: "Notch 1 Keeps Pro-T cells on Track"— Presentation transcript:

1 Notch 1 Keeps Pro-T cells on Track
Harald von Boehmer  Immunity  Volume 30, Issue 1, Pages 5-7 (January 2009) DOI: /j.immuni Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 The Role of Notch Signaling in Pro-T Cells
In T cell development, Notch1 signaling in pro-T cells prevents them from differentiating into DCs and B cells (top). In contrast, Notch-deficient pro-T cells abort T cell development and generate DCs and thymic B cells that have deleted both Notch alleles and exhibit DJ rearrangements of the TCRβ locus (Dβ1Jβ1). In addition, B cells are generated that do not derive from Notch-deficient pro-T cells by an as-yet-unknown mechanism. Immunity  , 5-7DOI: ( /j.immuni ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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