1. Challenges

2. Deep Sequencing Signatures
Problems
Genomic data deluge from TCR repertoire sequencing
Problems: Data management, Visualization, Analyses
GOAL: Build a diagnostic tool
Millions of cells
BLOOD
B-Cell
T-Cell
INFECTION
T-SEQ
Deep Sequencing Signatures
IMMUNE SYSTEM

3. Tools Sequencers, Robots, Servers (cloud and local) Covaris
Local Servers
QIAcube robot
(DNA / RNA extractions)
Illumina Sequencer
Covaris
Bioanalyzer
Hudson Robotics
OpenTrons

4. Missing: Data Scientists, Bioinformaticists Manage the data deluge
Team
2 Computational scientists
2 Research Scientists
2 Technicians
1 Lab Manager
Founders: Ravi and Anitha
Missing: Data Scientists, Bioinformaticists
Manage the data deluge
Generate understanding

5. Projects Handle sequencing data from a variety of samples
Develop algorithms for analyzing TCR data
Develop methods to identify patterns in TCR and mtDNA data.
Develop databases and methods of visualizing data