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Upregulated SCPs in MFS mice Upregulated SCPs in MFS patients

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Presentation on theme: "Upregulated SCPs in MFS mice Upregulated SCPs in MFS patients"— Presentation transcript:

1 Upregulated SCPs in MFS mice Upregulated SCPs in MFS patients
-log10(p) B Upregulated SCPs in MFS patients -log10(p) Supplementary Figure 1

2 A B Supplementary Figure 2 Downregulated SCPs after baclofen treatment
in CMap database – baclofen (experiment # 2036) -log10(p) B Downregulated SCPs after baclofen treatment in CMap database – baclofen (all experiments combined) -log10(p) Supplementary Figure 2

3 Supplementary Figure 3 A B Downregulated SCPs in WT mice +/- BAC
-log10(p) B Downregulated SCPs in MFS mice +/- BAC -log10(p) Supplementary Figure 3

4 Supplementary Fig. 4 A 25 50 100 75 Percent Survival 30 60 90
25 50 100 75 Percent Survival 30 60 90 Days After Birth WT VEH MFS ENA MFS VEH MFS PRO ns B 0.00 0.05 0.10 0.15 0.20 0.25 0.00 0.05 0.10 0.15 0.20 0.25 0.30 AoR Diameter (cm) AsA Diameter (cm) WT MFS MFS MFS WT MFS MFS MFS VEH VEH PRO ENA VEH VEH PRO ENA Supplementary Fig. 4

5 Supplementary Fig. 5 A B C WT VEH MFS BAC
Circumferential Stiffness (MPa) 2 4 6 8 WT VEH MFS BAC Circumferential Stress (kPa) 200 400 600 WT VEH MFS BAC Stored Elastic Energy (kPa) 50 100 150 Supplementary Fig. 5

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Fig. 4-1, p. 107. Fig. 4-2, p. 109 Fig. 4-3, p. 110.

Fig. 4-1, p Fig. 4-2, p. 109 Fig. 4-3, p. 110.
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