2. Content 1 Introduction 2 Etiology 3 Epidemology 4 Clinical Signs 5 Pathogenesis 6 Diagnosis 7 Treatment 8 Vaccination 9 Control

3. Foot and Mouth Disease Aphthous fever Tiger Heart Highly contagious Some time fatal Viral disease of cloven-footed animals cattle, buffalo, sheep and goats Occurrence Asia, Africa,Europe the Middle East and South America

4. 1.ETIOLOGY  causative agent Family Picornaviridae genus Aphthovirus.  serotypes:  A  O  C  SAT1  SAT2  SAT3  Asia-1

5.  Temperature: progressively inactivated by temperatures above 50°C  pH: Inactivated by pH 9.0  Disinfectants: Inactivated by sodium hydroxide (2%), sodium carbonate (4%), and citric acid (0.2%).

6. Hosts Bovine Sheep Goat Camel Swine Low mortality rate adult animals Oftenly high mortality young due to myocarditis

7. Transmission Animate vectors Inanimate vectors Clinically affected animals Inhalation  People wearing contaminated clothes or footwear or using contaminated equipment  Hay, feedstuffs, contaminated with the virus.  Contaminated water

8. 3. Clinical signs  Drooling of saliva Sticky, foamy  Anoraxia  Shivering  Pyraxia Raised temperature. (104-106 F)  Reduced milk yield  Lameness with reluctance to move  Sores and blisters on the feet, in the mouth or on the tongue  In case of females Sores and blisters on teat  Oftenly high mortality young due to myocarditis  Low feed intake painful tongue & mouth lesions

11. Postmortem findings :  Necrosis of heart muscle (tiger heart), usually only in young acutely infected animals.  Ulcerative lesions on tongue, palate, gums, pillars of the rumen and feet

12. 4. Pathogenesis  Infection through inhalation, the most efficient method of infection, virus can also gain entry to tissues through ingestion, insemination and inoculation, and through contact with abraded skin..  Primary viral replication, after inhalation,takes place in the mucosal and lymphatic tissues of the pharynx.  Viraemia follows primary multiplication with further viral replication in lymph nodes, mammary glands and other organs as well as the epithelial cells of the mouth, muzzle, teats, interdigital skin and coronary band.  In these areas of stratified squamous epithelium, vesicle formation results from swelling and rupture of keratinocytes in the stratum spinosum

13. 5. Diagnosis  Clinical signs  For Lab tests take 1g epithelium of lesions (ruptured or not)  ELISA  Complement fixation test  Serological tests  ELISA  Virus neutralisation test All submissions should accompany a history

15. 6. Treatment  Treatment usually not practiced, in some cases o Anti-pyretics o Anti-biotics  It is recommended that at the face of an outbreak, isolation and slaughter of diseased animals should be done  Animals at risk must be vaccinated and tested serologically in regular intervals of time. o Vaccination failure may occur due to Lack of the prevailing serotype, Poor amount of immunogen in the vaccine

16.  Proper Vaccine Schedule at the Farm with good Quality Vaccine  Vaccinate all the healthy animals with good quality vaccine including infected animals to minimize the shedding if FMD Virus. FMD VRI vaccine: Aftovac pure INACTIVATED VACCINE: Aftovax  Vaccinate only healthy animals 7. Vaccination

17. 8. Control  Disinfection  Disinfect equipments and floor with house hold bleach (2 parts with 3 parts water mixed thoroughly)  Remove all organic matter Manure, dirt, feed, etc. Vehicles, shoes, equipment Arrange separate cover-alls for laborers for work place.  Improve vaccination procedure with cold chain

18. 8. Losses due to FMD  About six Arab losses are due to FMD in Pakistan annually.  Production losses are more as compare to mortality.  Reduced milk production cause huge economic losses to farmers and on the national economy.  Milk production may be permanently affected, even in animals that have recovered  FMD can devastate industry early detection and response is key to minimizing economic impact.

19.  Separate the Infected animals from healthy ones  Livestock farmer have proper vaccine schedule on his farm with good quality vaccine or consult local veterinarian for good quality FMD vaccine.  If you suspect disease in any of your animals you must contact your local veterinarian.  And not to send your animals outside for grazing. Any delay could allow the disease to spread further.