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An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment  Eli O. Meltzer, MD, Robert B. Berkowitz,

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Presentation on theme: "An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment  Eli O. Meltzer, MD, Robert B. Berkowitz,"— Presentation transcript:

1 An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment  Eli O. Meltzer, MD, Robert B. Berkowitz, MD, Elliott B. Grossbard, MD  Journal of Allergy and Clinical Immunology  Volume 115, Issue 4, Pages (April 2005) DOI: /j.jaci Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Allergen cross-binding to IgE bound to Fcε receptor on mast cell initiates lyn phosphorylation of receptor and Syk activation with downstream effects that include degranulation as well as lipid mediator and cytokine synthesis and release. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Park study schedule of events. bid, Two times daily; ECG, electrocardiogram; SGA, subject global assessment; SGTR, subject global therapeutic response. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Comparison of improvement (%) in individual symptoms and overall GSC between patients receiving R112 and those receiving placebo. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

5 Fig 4 GSC score over time; park day 1 and 2.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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