1. Cryo-EM Captures the Dynamics of Ion Channel Opening
John L. Rubinstein 
Cell 
Volume 168, Issue 3, Pages (January 2017)
DOI: /j.cell
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1 The Opening of Slo2.2, a Neuronal Na+-Activated K+ Channel
(A) Slo2.2 channels exist in an open state that allows K+ movement across the membrane or a closed state that does not. As the concentration of Na+ increases, the probability of an individual channel opening increases and the total K+ permeability of the membrane increases.
(B) The open and closed states correspond to different conformations of the protein. Hite and MacKinnon have determined the structures of these conformations. They also show that the populations of 3D classes of cryo-EM images corresponding to each structure behave similarly to the open probability of the channel as the Na+ concentration is varied.
Cell  , DOI: ( /j.cell )
Copyright © 2017 Elsevier Inc. Terms and Conditions