1. Dose-dependent growth inhibition assays of fluconazole and DM262.
Dose-dependent growth inhibition assays of fluconazole and DM262. A 2-fold dilution series of fluconazole and DM262 in DMSO treatment in a variety of pathogenic fungal species. OD was measured in wideband (420 to 580 nm) to measure turbidity while accounting for differences in medium color. The difference in growth inhibition between fluconazole and DM262 is shown in Cryptococcus neoformans (A and B), Lomentospora prolificans (C and D), Cryptococcus gattii (E and F), and Candida albicans (G and H). Error bars represent standard deviations within technical triplicates. Each experiment had at least two biological replicates.
Eric H. Jung et al. mSphere 2018; doi: /mSphere