1. Apoptotic cell debris induces AXL-dependent cell migration.
Apoptotic cell debris induces AXL-dependent cell migration. A, Preparation and isolation of apoptotic cell debris and ABs from non–AXL-expressing HCC827 lung cancer cells by means of UV irradiation and centrifugation. B, Representative images of the wound density 24 hours after scratching a confluent MDA-MB-231-red monolayer, in the absence (left) and the presence of apoptotic cell debris (right). C, WCR of MDA-MB-231-red cells upon addition of apoptotic cell debris with or without 1 μmol/L R428 or 100 μg/mL warfarin. Data of three independent experiments are presented as log2 of median, with whiskers representing the 5 to 95 percentile of at least eight measurements per condition (*, P < 0.05; **, P < 0.01; ***, P < 0.001, Student t test).
Annelien J.M. Zweemer et al. Mol Cancer Res 2017;15:
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