1. Validation of NAA's cancer specificity in lung cancer.
Validation of NAA's cancer specificity in lung cancer. A, NAA levels in nine NSCLC cell lines, HBEC30KT, and HBEC34KT relative to its average level in H1299 cells. Error bars, standard errors of normalized NAA levels (N = 3). B, intracellular and extracellular NAA levels in 11 NSCLC cell lines and HBEC30KT. Data shown are averages of triplicate data. Error bars are omitted for clarity. C, NAA concentrations in control lung tissues (“control,” N = 5) and NSCLC tumors (“tumor,” N = 11). Horizontal lines and error bars indicate mean and standard errors of tissue NAA concentrations. D, gene expression levels of NAT8L, the key enzyme for NAA biosynthesis, in 55 adenocarcinoma (AD) lung tumors as compared with patient-matched nonmalignant lung tissues.
Tzu-Fang Lou et al. Cancer Prev Res 2016;9:43-52
©2016 by American Association for Cancer Research