1. Cellular pharmacology of F-ara-A and Cl-F-ara-A.
Cellular pharmacology of F-ara-A and Cl-F-ara-A. CLL lymphocytes were incubated for 2 h with escalating concentrations (1, 3, 5, 10, 20, 50, and 100 μm) of [8-3H]F-ara-A (A) or [8-3H]Cl-F-ara-A (B). Intracellular triphosphate levels were determined by high-performance liquid chromatography. Each symbol represents samples from one patient. C, CLL lymphocytes from 23 patients were incubated for 2 h with 10 μm [8-3H]F-ara-A or 10 μm [8-3H]Cl-F-ara-A. The relative accumulation of the two analogue triphosphates was compared in each sample. Each point represents samples from one patient.
Takahiro Yamauchi et al. Clin Cancer Res 2001;7:
©2001 by American Association for Cancer Research