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Fig. 2 EPP-associated hepatotoxicity is dependent on ABCG2.

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Presentation on theme: "Fig. 2 EPP-associated hepatotoxicity is dependent on ABCG2."— Presentation transcript:

1 Fig. 2 EPP-associated hepatotoxicity is dependent on ABCG2.
EPP-associated hepatotoxicity is dependent on ABCG2. WT, Abcg2-null, Fech-mut, and Fech-mut/Abcg2-null mice were kept under the same environment and euthanized at a similar age. (A to C) Serum activities of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP). (D) Serum total bilirubin. (E) PPIX in the liver, analyzed by UPLC-QTOFMS. The data are expressed as means ± SEM (n = 4 per group). ***P < 0.001, one-way ANOVA. (F to I) Representative liver sections with H&E staining. Arrows indicate bile plugs. Scale bars, 10 μm. PV, portal vein; BD, bile duct. Pengcheng Wang et al. Sci Adv 2019;5:eaaw6127 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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