1. BEZ235 induces accelerated senescence after radiation (IR) in vitro.
BEZ235 induces accelerated senescence after radiation (IR) in vitro. A, representative images of SA-βGal activity after 48 hours treatment (×200 magnification). B, percentage of SA-βGal positive cells. Data are mean ± SEM from 3 independent experiments. ***, P < 0.001; **, P < 0.01; *, P < C, Western blot showing total p21 levels after 48 hours treatment in H460 and A549 cells. DMSO, dimethyl sulfoxide.
Arun Azad et al. Mol Cancer Res 2011;9:
©2011 by American Association for Cancer Research