1. Advances in Portopulmonary Hypertension

3. PoPH

4. Defining PoPH

5. Hypothesis of PoPH Pathogenesis

6. TIPS Stent Placement

7. Epidemiology of PoPH

8. Survival and Prognostic Factors in PoPH

9. Multidisciplinary Approach in PoPH

10. Screening of PoPH

11. Additional Considerations in Diagnosing PoPH

12. PoPH Treatment Recommendations

13. Treatment of PoPH

14. Bosentan in PoPH (CP A and B)

15. PORTICO -- Macitentan in PoPH Study Design

16. PORTICO: Safety Considerations

17. PORTICO: Primary Endpoint

18. PORTICO: Secondary Endpoints*

19. PORTICO: Impact on Venous Pressure Gradient

20. Clinical Implications of PORTICO

21. Worsening of PoPH After LT

22. PORTICO Post Hoc Analysis: Improvement in Risk Categories Before LT

23. Treatment Algorithm for PoPH

24. Abbreviations

25. Abbreviations (cont)

26. Abbreviations (cont)