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Physical variables affecting FIO2 of nasal cannula with increasing breathing frequency (f), at flows from 1–5 L/min. Physical variables affecting FIO2 of nasal cannula with increasing breathing frequency (f), at flows from 1–5 L/min. Graphic and equation identify multiple factors that cause an exponential decline in volume of oxygen that can be inspired with increasing f. Tidal volume (VT) and dead space (VD) were held constant. V̇O2 = oxygen uptake. TI = inspiratory time. Ttot = total respiratory cycle time. (From Reference 24.) Jeffrey J Ward Respir Care 2013;58:98-122 (c) 2012 by Daedalus Enterprises, Inc.
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