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Volume 19, Issue 4, Pages (April 2014)

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1 Volume 19, Issue 4, Pages 551-552 (April 2014)
Small Molecules Convert Fibroblasts into Islet-like Cells Avoiding Pluripotent State  Nadya Lumelsky  Cell Metabolism  Volume 19, Issue 4, Pages (April 2014) DOI: /j.cmet Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Small Molecules Reprogram Mouse Embryonic Fibroblasts into Pancreatic Islet-like Cells Bypassing Pluripotent State Following induction of pluripotency genes, the unique combinations of small molecules guide direct reprogramming of embryonic fibroblasts into definitive endoderm-like cells, pancreatic progenitor-like cells, and pancreatic-like cells. This protocol is faster, more efficient, and potentially safer than earlier-developed protocols involving full reprogramming of fibroblasts into iPSCs followed by their differentiation into pancreatic-like cells. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2014 Elsevier Inc. Terms and Conditions


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