1. Cancer-associated pathways and biomarkers of venous thrombosis
by Yohei Hisada, and Nigel Mackman
Blood
Volume 130(13):
September 28, 2017
©2017 by American Society of Hematology

2. Neutrophilia increases thrombosis in lung cancer.
Neutrophilia increases thrombosis in lung cancer. Tumor-derived G-CSF leads to increased levels of neutrophils, and these neutrophils release NETs that increase thrombosis in patients with lung cancer. EC, endothelial cell.
Yohei Hisada, and Nigel Mackman Blood 2017;130:
©2017 by American Society of Hematology

3. Thrombocytosis increases thrombosis in ovarian cancer.
Thrombocytosis increases thrombosis in ovarian cancer. Tumor-derived IL-6 stimulates hepatocytes to express thrombopoietin (TPO), which increases platelet production and enhances thrombosis in patients with ovarian cancer.
Yohei Hisada, and Nigel Mackman Blood 2017;130:
©2017 by American Society of Hematology

4. Tumor-derived TF+ MVs trigger thrombosis in pancreatic cancer.
Tumor-derived TF+MVs trigger thrombosis in pancreatic cancer. Pancreatic tumor cells release TF+ MVs into the circulation that trigger thrombosis in patients with pancreatic cancer.
Yohei Hisada, and Nigel Mackman Blood 2017;130:
©2017 by American Society of Hematology

5. Tumor-derived, PDPN+ MVs trigger thrombosis in brain cancer.
Tumor-derived, PDPN+MVs trigger thrombosis in brain cancer. Brain tumor cells may release PDPN+ MVs that activate circulating platelets and increase thrombosis in patients with brain cancer.
Yohei Hisada, and Nigel Mackman Blood 2017;130:
©2017 by American Society of Hematology