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Multitalented E2A: A New Role in Lymphoid-Lineage Priming

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Presentation on theme: "Multitalented E2A: A New Role in Lymphoid-Lineage Priming"— Presentation transcript:

1 Multitalented E2A: A New Role in Lymphoid-Lineage Priming
Motonari Kondo  Immunity  Volume 29, Issue 2, Pages (August 2008) DOI: /j.immuni Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 E2A Has Multiple Roles at Various Stages during Lymphocyte Development A recent model of early hematopoiesis is shown. Flt3loVCAM-1+ MPPs represent “classical” MPPs with true multipotent-differentiation potential. The granulocyte-macrophage-lymphoid progenitor (GMLP) overlaps greatly with Flt3hiVCAM-1+ MPP. Similarly, LMPP, ELP, and Flt3hiVCAM-1− MPP are thought to reside in the same or mostly overlapping population. The stages in which E2A has a role are indicated in this figure. GMP, granulocyte-macrophage progenitor; MEP, megakaryocyte-erythrocyte progenitor; ETP, early T cell progenitor. Immunity  , DOI: ( /j.immuni ) Copyright © 2008 Elsevier Inc. Terms and Conditions


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