Presentation is loading. Please wait.

Presentation is loading. Please wait.

The role of RAI2 in breast cancer metastasis.

Published byGülistan Bakkal Modified over 5 years ago

Similar presentations

Presentation on theme: "The role of RAI2 in breast cancer metastasis."— Presentation transcript:

1 The role of RAI2 in breast cancer metastasis.
The role of RAI2 in breast cancer metastasis. Differentiated breast cancer cells exhibit high levels of RAI2, which binds to the transcriptional corepressor C-terminal binding protein-2 (CTBP2) through a conserved ALDLS sequence, preventing it from suppressing the expression of breast cancer differentiation transcription factor genes GATA3, FOXOA1, and GRHL2. Metastatic cells lose expression of RAI2, allowing the suppression of differentiation transcription factors by CTBP2, and the development of EMT features that facilitate tumor dissemination. Mark Esposito, and Yibin Kang Cancer Discovery 2015;5: ©2015 by American Association for Cancer Research

Download ppt "The role of RAI2 in breast cancer metastasis."

Similar presentations

20,000 GENES IN HUMAN GENOME; WHAT WOULD HAPPEN IF ALL THESE GENES WERE EXPRESSED IN EVERY CELL IN YOUR BODY? WHAT WOULD HAPPEN IF THEY WERE EXPRESSED.

20,000 GENES IN HUMAN GENOME; WHAT WOULD HAPPEN IF ALL THESE GENES WERE EXPRESSED IN EVERY CELL IN YOUR BODY? WHAT WOULD HAPPEN IF THEY WERE EXPRESSED.
THE GENETIC OF CANCER Increased mitosisTumor formation Tumor suppression gene Hyperactive growth TranslocationPoint mutationAmplification Normal growth.

THE GENETIC OF CANCER Increased mitosisTumor formation Tumor suppression gene Hyperactive growth TranslocationPoint mutationAmplification Normal growth.
1 April, 2005 Chapter C4.1 and C5.1 DNA Microarrays and Cancer.

1 April, 2005 Chapter C4.1 and C5.1 DNA Microarrays and Cancer.
BRCA1 The First Breast Cancer Gene Presentation By Liz Mosley.

BRCA1 The First Breast Cancer Gene Presentation By Liz Mosley.
Control of the Cell Cycle. Cyclins Cell cycle is controlled by proteins called cyclins and a set of enzymes that attach to the cyclin and become activated.

Control of the Cell Cycle. Cyclins Cell cycle is controlled by proteins called cyclins and a set of enzymes that attach to the cyclin and become activated.
Control of Gene Activity Chapter 17. Controlling gene activity Remember to control the cell one must control protein synthesis. Remember to control the.

Control of Gene Activity Chapter 17. Controlling gene activity Remember to control the cell one must control protein synthesis. Remember to control the.
BioH Chapter 14 – Control over Genes. Control of Gene Expression Cells are selective about which genes they require This depends upon:  Cell type  Specific.

BioH Chapter 14 – Control over Genes. Control of Gene Expression Cells are selective about which genes they require This depends upon:  Cell type  Specific.
Gene regulation results in differential gene expression, leading to cell specialization.

Gene regulation results in differential gene expression, leading to cell specialization.
Gene Expression Control of Gene Expression Activation of a gene that results in the formation of a _________. When transcription occurs a gene is “__________”

Gene Expression Control of Gene Expression Activation of a gene that results in the formation of a _________. When transcription occurs a gene is “__________”
8.6 Gene Expression and Regulation TEKS 5C, 6C, 6D, 6E KEY CONCEPT Gene expression is carefully regulated in both prokaryotic and eukaryotic cells.

8.6 Gene Expression and Regulation TEKS 5C, 6C, 6D, 6E KEY CONCEPT Gene expression is carefully regulated in both prokaryotic and eukaryotic cells.
Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.
Gene Regulation Packet #46 Chapter #19.

Gene Regulation Packet #46 Chapter #19.
ROLE OF GENE EXPRESSION:  Activation of a gene that results in a protein  Cells DO NOT need to produce proteins for every code. GENOME:  Complete genetic.

ROLE OF GENE EXPRESSION:  Activation of a gene that results in a protein  Cells DO NOT need to produce proteins for every code. GENOME:  Complete genetic.
1. Epithelial Mesenchymal Transition ( EMT ) 2 3.

1. Epithelial Mesenchymal Transition ( EMT ) 2 3.
Case Study: Characterizing Diseased States from Expression/Regulation Data Tuck et al., BMC Bioinformatics, 2006.

Case Study: Characterizing Diseased States from Expression/Regulation Data Tuck et al., BMC Bioinformatics, 2006.
February 24, 2014 Write down definitions for: o Intron o Exon o pre-mRNA.

February 24, 2014 Write down definitions for: o Intron o Exon o pre-mRNA.
 Made of certain proteins.  Directs the timing and sequence of events in the cell cycle.  If something goes wrong, Cells lose control of cell cycle.

 Made of certain proteins.  Directs the timing and sequence of events in the cell cycle.  If something goes wrong, Cells lose control of cell cycle.
KEY CONCEPT Gene expression is carefully regulated in both prokaryotic and eukaryotic cells. Chapter 11 – Gene Expression.

KEY CONCEPT Gene expression is carefully regulated in both prokaryotic and eukaryotic cells. Chapter 11 – Gene Expression.
Lesson Overview Lesson Overview Gene Regulation and Expression Do Now (notes 1.Write this original sequence of DNA bases (this is the template) 2.Use DNA.

Lesson Overview Lesson Overview Gene Regulation and Expression Do Now (notes 1.Write this original sequence of DNA bases (this is the template) 2.Use DNA.
Gene Expression (Epigenetics) Chapter 19. What you need to know The functions of the three parts of an operon. The role of repressor genes in operons.

Gene Expression (Epigenetics) Chapter 19. What you need to know The functions of the three parts of an operon. The role of repressor genes in operons.

Similar presentations

Ads by Google