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RRP1B interacts with TRIM28 and HP1α at regions associated with H3K9me3 and decreased gene expression. RRP1B interacts with TRIM28 and HP1α at regions.

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Presentation on theme: "RRP1B interacts with TRIM28 and HP1α at regions associated with H3K9me3 and decreased gene expression. RRP1B interacts with TRIM28 and HP1α at regions."— Presentation transcript:

1 RRP1B interacts with TRIM28 and HP1α at regions associated with H3K9me3 and decreased gene expression. RRP1B interacts with TRIM28 and HP1α at regions associated with H3K9me3 and decreased gene expression. A, ChIP-reChIP with TRIM28 and RRP1B antibodies in MDA-MB-231 cells. *, P ≤ 0.05, compared with both IgG/TRIM28 and IgG/RRP1B controls. B, ChIP-reChIP with HP1α and RRP1B antibodies in MDA-MB-231 cells. *, P ≤ 0.05, compared with both IgG/HP1α and IgG/RRP1B controls. C, H3K9me3 ChIP-qPCR in MDA-MB-231 clonal isolates overexpressing RRP1B and control cell lines. D, H3K9me3 ChIP-qPCR in MDA-MB-231 cells transfected with either RRP1B siRNA or negative control siRNA. E, Venn diagram of unique and common H3K9me3-enriched regions identified by ChIP-seq in MDA-MB-231 clonal isolates overexpressing RRP1B and control cell lines. Minnkyong Lee et al. Mol Cancer Res 2014;12: ©2014 by American Association for Cancer Research

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