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One Small Step for Muscle: A New Micropeptide Regulates Performance

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Presentation on theme: "One Small Step for Muscle: A New Micropeptide Regulates Performance"— Presentation transcript:

1 One Small Step for Muscle: A New Micropeptide Regulates Performance
Joanne Tonkin, Nadia Rosenthal  Cell Metabolism  Volume 21, Issue 4, Pages (April 2015) DOI: /j.cmet Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Enhancing Muscle Performance by Restricting MLN
In normal muscle cells (left), MLN (dark red) binds to SERCA (blue) in the membrane of the sarcoplasmic reticulum (SR) and restricts the import of calcium. In reduced MLN (right), SERCA pump activity is liberated to keep calcium high in the SR lumen, resulting in higher calcium availability and increased export by ryanodine receptors (orange) to increase contraction of working muscle cells and improve performance. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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