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ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF- Mediated Snail Nuclear Localization: Implications for Gleason Grading  Paul.

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Presentation on theme: "ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF- Mediated Snail Nuclear Localization: Implications for Gleason Grading  Paul."— Presentation transcript:

1 ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF- Mediated Snail Nuclear Localization: Implications for Gleason Grading  Paul Mak, Irwin Leav, Bryan Pursell, Donggoo Bae, Xiaofang Yang, Cherie A. Taglienti, Lindsey M. Gouvin, Vishva M. Sharma, Arthur M. Mercurio  Cancer Cell  Volume 17, Issue 6, (June 2010) DOI: /j.ccr Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 4 ERβ1 Destabilizes HIF-1α Protein and Represses HIF-1-Mediated Transcription of VEGF-A (C) PC3 cells (scrambled control cells) or ERβ1 knockdown cells were treated in the absence or presence of MG132 (1 uM) for 6 hr and photographed. Scale bars represent 50 um. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2010 Elsevier Inc. Terms and Conditions

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