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Rafal S. Sobota, Catherine M. Stein, Nuri Kodaman, Laura B

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Presentation on theme: "Rafal S. Sobota, Catherine M. Stein, Nuri Kodaman, Laura B"— Presentation transcript:

1 A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals 
Rafal S. Sobota, Catherine M. Stein, Nuri Kodaman, Laura B. Scheinfeldt, Isaac Maro, Wendy Wieland-Alter, Robert P. Igo, Albert Magohe, LaShaunda L. Malone, Keith Chervenak, Noemi B. Hall, Chawangwa Modongo, Nicola Zetola, Mecky Matee, Moses Joloba, Alain Froment, Thomas B. Nyambo, Jason H. Moore, William K. Scott, Timothy Lahey, W. Henry Boom, C. Fordham von Reyn, Sarah A. Tishkoff, Giorgio Sirugo, Scott M. Williams  The American Journal of Human Genetics  Volume 98, Issue 3, Pages (March 2016) DOI: /j.ajhg Copyright © 2016 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Results for Imputed SNPs in a 50 kb Region around rs from an Additive Genetic Model for Association with TB in the Combined Cohort The imputed SNP with the most significant association, rs , is in a purple. Colors represent LD (measured with r2) between available variants and rs Annotation of chromatin-state segmentation in the zoomed region around rs is from the UCSC Genome Browser (hg19) for nine human cell types (chr5: 158,680,000–158,700,000). Bright red indicates an active promoter, light red indicates a weak promoter, yellow represents a weak or poised enhancer, light green represents a weak transcribed state, and dark green indicates transcriptional transition or elongation. An H3K27Ac histone mark aligns with the most significant SNPs. The American Journal of Human Genetics  , DOI: ( /j.ajhg ) Copyright © 2016 The American Society of Human Genetics Terms and Conditions

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