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Kidney Cancer: Now Available in a New Flavor

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Presentation on theme: "Kidney Cancer: Now Available in a New Flavor"— Presentation transcript:

1 Kidney Cancer: Now Available in a New Flavor
William G. Kaelin  Cancer Cell  Volume 14, Issue 6, Pages (December 2008) DOI: /j.ccr Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Clear Cell Renal Carcinoma Subtypes
pVHL targets HIFα for proteasomal degradation. Accordingly, tumors with wild-type pVHL have low levels of HIFα. pVHL-defective tumors can be subdivided based on whether they accumulate both HIF1α and HIF2α (H1H2) or HIF2α alone (H2). In the former, HIF1α antagonizes c-Myc. In the latter, this antagonism is lost and c-Myc activity is therefore increased. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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