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Published byFabienne Beauchemin Modified over 5 years ago
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Chimeric antigen receptor–modified T cells: CD19 and the road beyond
by Alexander I. Salter, Margot J. Pont, and Stanley R. Riddell Blood Volume 131(24): June 14, 2018 ©2018 by American Society of Hematology
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CAR design. CAR design. (A) Schematic of TCR and costimulatory molecule expression on T cells. (B-C) Synthetic single-chain receptors designed to deliver modified signal 1 and signal 2 in an scFv/CD28/CD3ζ (B) or scFv/4-1BB/CD3ζ format (C). Alexander I. Salter et al. Blood 2018;131: ©2018 by American Society of Hematology
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CAR toolbox. CAR toolbox. Toolbox of applications in synthetic biology that may extend and enhance the efficacy and safety of ACT. Alexander I. Salter et al. Blood 2018;131: ©2018 by American Society of Hematology
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