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Published byAnnette Gjertsen Modified over 5 years ago
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Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability
Anthony N. Imbalzano, Stephen N. Jones Cancer Cell Volume 7, Issue 4, Pages (April 2005) DOI: /j.ccr Copyright © 2005 Elsevier Inc. Terms and Conditions
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Figure 1 Modulation of the Rb tumor suppressor pathway by hSNF5
By increasing expression of p16 and inhibiting expression of cyclin D1, SNF5 promotes the inactivation of E2F transcription factors by Rb, thereby negatively regulating cell growth and maintaining numerical chromosomal stability. Tumor suppressor proteins are shown in blue. Cancer Cell 2005 7, DOI: ( /j.ccr ) Copyright © 2005 Elsevier Inc. Terms and Conditions
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