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Signaling Tug-of-War Delivers the Whole Message

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1 Signaling Tug-of-War Delivers the Whole Message
Andrea Y. Weiße, Ahmad A. Mannan, Diego A. Oyarzún  Cell Systems  Volume 3, Issue 5, Pages (November 2016) DOI: /j.cels Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Input-Output View of Signaling Pathways
(A) Typical signaling system composed of a membrane-bound receptor and an intracellular signaling cascade. Signaling systems have different dose-response curves from ligand concentration to occupied receptors and downstream signaling. (B) Block diagram of a signaling system. When the dose-response curves are perfectly aligned, the signaling cascade maps receptor occupancy into downstream activation in a linear fashion. Misalignment of the dose-response curves in (A) causes the cascade to behave as a nonlinear amplifier with varied input-output responses. Cell Systems 2016 3, DOI: ( /j.cels ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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