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Nucleophilic Substitution: Alkylation of α Carbons

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Presentation on theme: "Nucleophilic Substitution: Alkylation of α Carbons"— Presentation transcript:

1 Nucleophilic Substitution: Alkylation of α Carbons

2 Determining Thermodynamic Enolate

3 Determining Kinetic Enolate

4 Polyhalogenation of α Carbons under basic conditions

5 Formation of Ethers

6 Williamson’s Ether Synthesis
Green Principles Addresses Less Hazardous Reagents Safer Solvent Use of renewable feedstocks

7 Intramolecular Williamson Ether Syntheses

8 Reactions of Epoxides under Neutral and Basic Conditions

9 Reactions of Epoxides under Neutral and Basic Conditions (cont)

10 Reactions of Epoxides under Neutral and Basic Conditions (cont)
67_p549_Karty1_CH10

11 Reactions of Epoxides under Neutral and Basic Conditions (cont)
68_p549_Karty1_CH10

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