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Coupling of myosin to integrins in cancer spheroids is required for mesothelial clearance. Coupling of myosin to integrins in cancer spheroids is required.

Published byBlaise Manning Modified over 5 years ago

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Presentation on theme: "Coupling of myosin to integrins in cancer spheroids is required for mesothelial clearance. Coupling of myosin to integrins in cancer spheroids is required."— Presentation transcript:

1 Coupling of myosin to integrins in cancer spheroids is required for mesothelial clearance.
Coupling of myosin to integrins in cancer spheroids is required for mesothelial clearance. A, Western blot of nonmuscle myosin heavy chain A and B (NM IIA or NM IIB) expression levels in control or NM IIA/NM IIB shRNA–treated OVCA433 cells. B, images show the temporal behavior of mesothelial cells contacting control or myosin shRNA–expressing OVCA433 ovarian cancer cells. Scale bar, 50 μm. C, quantification of mesothelial clearance from B. A total of 20 spheroid attachment sites were analyzed per condition. D, Western blot of talin I expression levels in control or talin I shRNA–expressing OVCA433 cells. E, images show temporal behavior of mesothelial cells contacting control or talin I shRNA–expressing OVCA433 ovarian cancer cells. Scale bar, 50 μm. F, quantification of mesothelial clearance from E. A total of 15 randomly chosen regions were analyzed per condition. Marcin P. Iwanicki et al. Cancer Discov 2011;1: ©2011 by American Association for Cancer Research

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