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Cells expressing mutant NADK-I90F exhibit low ROS and elevated NADP and NADPH levels. Cells expressing mutant NADK-I90F exhibit low ROS and elevated NADP.

Published byRoderick Sutton Modified over 5 years ago

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Presentation on theme: "Cells expressing mutant NADK-I90F exhibit low ROS and elevated NADP and NADPH levels. Cells expressing mutant NADK-I90F exhibit low ROS and elevated NADP."— Presentation transcript:

1 Cells expressing mutant NADK-I90F exhibit low ROS and elevated NADP and NADPH levels.
Cells expressing mutant NADK-I90F exhibit low ROS and elevated NADP and NADPH levels. Total NADP and NADPH (NADPt) and NADPH levels were determined in normal pancreatic ductal cells (HPDE); pancreatic ductal adenocarcinoma cells (BxPC-3 and Panc-1); or cell lines expressing either the vector control, NADK, or NADK-I90F using the NADP/NADPH-Glo assay (Promega; A). ROS levels were assayed in normal pancreatic ductal cells (HPDE) or pancreatic cancer cells (BxPC-3 and Panc-1; B). Expression levels of NADK and NADK-I90F were determined (C). Adapted from Tsang and colleagues (37). Philip M. Tedeschi et al. Clin Cancer Res 2016;22: ©2016 by American Association for Cancer Research

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