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George E. Sarris, MDa, Kathleen A. Moore, BSa, John S

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Presentation on theme: "George E. Sarris, MDa, Kathleen A. Moore, BSa, John S"— Presentation transcript:

1 Cardiac transplantation: The Stanford experience in the cyclosporine era 
George E. Sarris, MDa, Kathleen A. Moore, BSa, John S. Schroeder, MDb, Sharon A. Hunt, MDb, Michael B. Fowler, MDb, Hannah B. Valantine, MDb, Randall H. Vagelos, MDb, Margaret E. Billingham, MDc, Philip E. Oyer, MD, PhDa, Edward B. Stinson, MDa, Bruce A. Reitz, MDa, Norman E. Shumway, MD, PhDa  The Journal of Thoracic and Cardiovascular Surgery  Volume 108, Issue 2, Pages (August 1994) DOI: /uri:pii:S Copyright © 1994 Mosby, Inc. Terms and Conditions

2 Fig. 1 Distribution of recipient diagnoses.
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

3 Fig. 2 Age distribution of the recipient and donor patient populations. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

4 Fig. 3 Causes of operative (A) and overall deaths (B).
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

5 Fig. 3 Causes of operative (A) and overall deaths (B).
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

6 Fig. 4 Actuarial survival for the entire patient population. Error bars in this and all figures represent ±1 standard error of the mean. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

7 Fig. 5 Actuarial freedom from rejection for the entire group of patients. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

8 Fig. 6 Linearized rejection rates for current protocol (group I) and all other patients. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

9 Fig. 7 Actuarial freedom from rejection-related death for the entire group of patients. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

10 Fig. 8 Actuarial freedom from infection (A) and from infection-related death (B) for all patients. C, Actuarial freedom from infection with the major classes of pathogens. D, Actuarial freedom from infection for patients operated on before and after 1987. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

11 Fig. 8 Actuarial freedom from infection (A) and from infection-related death (B) for all patients. C, Actuarial freedom from infection with the major classes of pathogens. D, Actuarial freedom from infection for patients operated on before and after 1987. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

12 Fig. 8 Actuarial freedom from infection (A) and from infection-related death (B) for all patients. C, Actuarial freedom from infection with the major classes of pathogens. D, Actuarial freedom from infection for patients operated on before and after 1987. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

13 Fig. 8 Actuarial freedom from infection (A) and from infection-related death (B) for all patients. C, Actuarial freedom from infection with the major classes of pathogens. D, Actuarial freedom from infection for patients operated on before and after 1987. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

14 Fig. 9 Actuarial freedom from graft CAD (A) from CAD-related death (B), and from CAD-related death or retransplantation (C). D, Actuarial freedom from graft CAD according to donor age. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

15 Fig. 9 Actuarial freedom from graft CAD (A) from CAD-related death (B), and from CAD-related death or retransplantation (C). D, Actuarial freedom from graft CAD according to donor age. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

16 Fig. 9 Actuarial freedom from graft CAD (A) from CAD-related death (B), and from CAD-related death or retransplantation (C). D, Actuarial freedom from graft CAD according to donor age. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

17 Fig. 9 Actuarial freedom from graft CAD (A) from CAD-related death (B), and from CAD-related death or retransplantation (C). D, Actuarial freedom from graft CAD according to donor age. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

18 Fig. 10 Renal function parameters remained relatively stable after an initial decline early after the operation. BUN, Blood urea nitrogen. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

19 Fig. 11 Blood pressure (BP) rises early after transplantation but remains stable thereafter. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

20 Fig. 12 Doses over time of the three primary immunosuppressive agents used. CYA, Cyclosporine; Pred, prednisone; AZA, azathioprine. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

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