1. Effects of vitamin K antagonists (VKA), such as warfarin, low-molecular-weight heparin (LMWH), and dabigatran, on the coagulation pathway.
Effects of vitamin K antagonists (VKA), such as warfarin, low-molecular-weight heparin (LMWH), and dabigatran, on the coagulation pathway. VKAs indirectly inhibit both the intrinsic and extrinsic pathways. LMWH indirectly inhibit factor Xa and thrombin via inhibition of antithrombin (AT). Dabigatran directly inhibits factor IIa (thrombin). UFH, unfractionated heparin.
Felix Knauf et al. CJASN 2013;8:
©2013 by American Society of Nephrology