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Marking Emerging β- and γδ-Selected T Cells

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1 Marking Emerging β- and γδ-Selected T Cells
Cornelis Murre  Immunity  Volume 24, Issue 1, Pages (January 2006) DOI: /j.immuni Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Model Outlining Early Regulatory Events in Emerging β- and γδ-Selected T Lineage Cells Regulation of transcription factors in emerging β- and γδ-selected T cells. Upon pre-TCR-mediated signaling, Id3 expression is elevated in DN3b cells, whereas that of HEB transcripts are decreased and E47 abundance is lowered as a direct result of both Id3 inhibition and signaling through the TCR, ultimately resulting in a decrease in E protein DNA binding activity. In emerging γδ T cells, the expression of Egr2, Egr3, and Id3 is increased, whereas that of HEB transcripts are lowered. Immunity  , 11-13DOI: ( /j.immuni ) Copyright © 2006 Elsevier Inc. Terms and Conditions


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