1. Constantijn Franssen et al. JCHF 2016;4:312-324
Microvascular Inflammation in HFpEF Patients and ZSF1-HFpEF Rats (A) ICAM-1 expression was higher in HFpEF than in AS (#p < 0.05 vs. AS;*p < 0.05 vs. HFrEF). (B) E-selectin levels were higher in HFpEF patients than in those with HFrEF and AS (#p < 0.05 vs. AS; *p < 0.05 vs. HFrEF). Expression levels of ICAM-1 (C) and E-selectin (D) were higher in ZSF1-HFpEF myocardium than in that of ZSF1-Ctrls (*p < 0.05). (E and F) ZSF1-HFpEF rats had higher levels of myocardial CD68 and MPO than ZSF1-Ctrls (*p < 0.05). AS = aortic stenosis; Ctrls = controls; HFpEF = heart failure with preserved ejection fraction; HFrEF = heart failure with reduced ejection fraction; ICAM = intercellular adhesion molecule; MPO = myeloperoxidase.
Constantijn Franssen et al. JCHF 2016;4:
American College of Cardiology Foundation