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Rapid nucleotide exchange allows irreversible interactions between GDP-bound KRASG12C (middle) and ARS-853 (right). Rapid nucleotide exchange allows irreversible.

Published byTor-Erik Philip Kristoffersen Modified over 5 years ago

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Presentation on theme: "Rapid nucleotide exchange allows irreversible interactions between GDP-bound KRASG12C (middle) and ARS-853 (right). Rapid nucleotide exchange allows irreversible."— Presentation transcript:

1 Rapid nucleotide exchange allows irreversible interactions between GDP-bound KRASG12C (middle) and ARS-853 (right). Rapid nucleotide exchange allows irreversible interactions between GDP-bound KRASG12C (middle) and ARS-853 (right). Of note, ARS-853 does not bind well to the GTP-bound form of KRASG12C (left) because the Switch II pocket is closed in that form. Switch II is shown in green, GTP in red, GDP in blue, and ARS-853 in yellow. RAS graphics were derived from Protein Data Bank ID 3F2D and 1ZW6. Kenneth D. Westover et al. Cancer Discov 2016;6: ©2016 by American Association for Cancer Research

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