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Fig. 3. miR302-367 overexpression leads to increased cell proliferation as well as altered differentiation and metabolism in cardiomyocytes. miR302-367.

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Presentation on theme: "Fig. 3. miR302-367 overexpression leads to increased cell proliferation as well as altered differentiation and metabolism in cardiomyocytes. miR302-367."— Presentation transcript:

1 Fig. 3. miR overexpression leads to increased cell proliferation as well as altered differentiation and metabolism in cardiomyocytes. miR overexpression leads to increased cell proliferation as well as altered differentiation and metabolism in cardiomyocytes. (A) Wheat germ agglutinin and α-actinin staining of hearts at P20. Cell surface area was quantified at E18.5 and P20. Quantitative analyses represent counting of five fields from three independent samples per group. (B) Heatmap and pathways profile of microarray analysis of Nkx2.5cre and Nkx2.5cre:R26R-miR Tg/+ mutant hearts at P14. (C and D) Gene expression changes related to cell proliferation (C) and programmed cell death (D) at P14. (E and F) Gene expression changes related to differentiation (E) and fatty acid metabolism (F) at P14 and P23. Data are means ± SEM (n = 3 per group). *P < 0.05 versus Nkx2.5cre control animals (Student’s t test). Ying Tian et al., Sci Transl Med 2015;7:279ra38 Copyright © 2015, American Association for the Advancement of Science

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